中文名称:渥曼青霉素

中文别名:渥曼青霉素,来源于黄色;WORTMANNIN 渥曼青霉素;抗生素SL-2052;渥曼青霉素, 一种多靶点抑制剂,抑制PI3K和MLCK;沃氏篮酶素;奥特曼宁;渥曼青霉素;PI3K和MLCK活性抑制剂(WORTMANNIN)

英文名称:WORTMANNIN

英文别名:antibioticsl-2052;sl-2052;[1S-(1ALPHA,6BALPHA,9ABETA,11ALPHA,11BBETA)]-11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[4,5-H]-2-BENZOPYRAN-3,6,9-TRIONE;KY 1242;Wortmannin from Talaromyces (Penicillium);3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-,(1S,6bR,9aS,11R,11bR)-;Wortmannin KY 1242;Wortmannin (+)-Wortmannin

CAS:19545-26-7

EINECS:606-337-5

分子式:C23H24O8

分子量:428.43

分子结构:

危险标志:    

风险术语:-

安全术语:接触皮肤后，立即用大量…（由制造商规定）、穿戴合适的防护服、戴上合适的手套、如果发生事故或感到不适，请就医立即提出建议（如有可能，展示标签）、佩戴眼部/面部防护用品、如果接触眼睛，请立即用大量清水冲洗喝水并寻求医疗建议、远离火源-禁止吸烟

物化性质:-

熔点:234-240 °C

相对密度:1.2454 (rough estimate)

溶解性:-

用途:一种PI3Ks和PLK1的特异性共价抑制剂。Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.

上游原料:17β-hydroxy Wortmannin

下游产品:-